(19)

(11)

EP 1 173 483 A1

(12)

(43) Date of publication: 23.01.2002 Bulletin 2002/04 (21) Application number: 00928590.9 (22) Date of filing: 28.04.2000

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 16/18, C12N 5/10, C12N 5/16, C12N 15/12, C12N 15/63, C12N 15/64, G01N 33/53, G01N 33/567 (86) International application number: PCT/US0011/606 (87) International publication number: WO 0064/943 (02.11.2000 Gazette 2000/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.04.1999 US 131379 P 27.04.2000 US 559439 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US)	(72) Inventors: HU, Erding Audubon, PA 19403 (US) SMITH, Randall, Forrest Lafayette Hill, PA 19444 (US) LI, Xiaotong Devon, PA 19333 (US) ZHU, Yuan Blue Bell, PA 19422 (US) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKline, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)