(19)

(11)

EP 1 173 485 A1

(12)

(43) Date of publication: 23.01.2002 Bulletin 2002/04 (21) Application number: 00944598.2 (22) Date of filing: 03.05.2000

(51) International Patent Classification (IPC)7: C07K 16/12, C07K 16/28, C07K 16/46, C12N 5/20, A61K 39/40, G01N 33/569, A61P 31/04, A01K 67/027 (86) International application number: PCT/US0012/116 (87) International publication number: WO 0071/585 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.05.1999 US 132212 P (71) Applicant: MEDAREX, INC. Annandale New Jersey 08801-0953 (US)	(72) Inventors: KELER, Tibor Ottsville, PA 18942 (US) DEO, Yashwant, M. Audubon, PA 19403 (US) (74) Representative: Holdcroft, James Gerald, Dr.  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)