(19)

(11)

EP 1 173 590 A2

(12)

(88) Date of publication A3: 15.02.2001 (43) Date of publication: 23.01.2002 Bulletin 2002/04 (21) Application number: 00922167.2 (22) Date of filing: 13.04.2000

(51) International Patent Classification (IPC)7: C12N 15/62, C12N 15/57, C12N 15/63, C12N 15/79 (86) International application number: PCT/US0009/973 (87) International publication number: WO 0066/709 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.04.1999 US 303162 (71) Applicant: Ortho-McNeil Pharmaceutical, Inc. Raritan, NJ 08869 (US)	(72) Inventors: DARROW, Andrew Lansdale, PA 19446 (US) QI, Jensen Branchburg, NJ 08876 (US) ANDRADE-GORDON, Patricia Doylestown, PA 18901 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)