(19)

(11)

EP 1 175 219 A1

(12)

(43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00932374.2 (22) Date of filing: 12.05.2000

(51) International Patent Classification (IPC)7: A61K 31/56, A01N 45/00 (86) International application number: PCT/US0013/101 (87) International publication number: WO 0067/757 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.05.1999 US 133740 P (71) Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US)	(72) Inventors: MARAN, Avudaiappan Rochester, MN 55901 (US) TURNER, Russell, T. Wabasha, MN 55981 (US) (74) Representative: Gassner, Wolfgang, Dr.  Patentanwalt Nägelsbachstrasse 49a 91052 Erlangen 91052 Erlangen (DE)