(19)

(11)

EP 1 175 223 A2

(12)

(88) Date of publication A3: 10.05.2001 (43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00923454.3 (22) Date of filing: 17.04.2000

(51) International Patent Classification (IPC)7: A61K 38/17, A61K 48/00, C07K 14/47, C12N 5/10, C12N 15/12, G01N 33/50, A61P 37/02 (86) International application number: PCT/US0010/340 (87) International publication number: WO 0063/241 (26.10.2000 Gazette 2000/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.04.1999 US 129772 P (71) Applicants: CHILDREN'S MEDICAL CENTER CORPORATION Boston Massachusetts 02115 (US) DANA-FARBER CANCER INSTITUTE, INC. Boston, MA 02115 (US)	(72) Inventors: ASHKAR, Samy Boston, MA 02115 (US) WEBER, Georg Chestnut Hill, MA 02647 (US) GLIMCHER, Melvyn Boston, MA 02130 (US) CANTOR, Harvey Wellesley, MA 02481 (US) (74) Representative: Holdcroft, James Gerald, Dr. et al Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)