UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY HMG-CoA REDUCTASE INHIBITORS - Patent 1175246

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EP 1 175 246 A1

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(43)	Date of publication:
	30.01.2002 Bulletin 2002/05

(21)	Application number: 00916511.9

(22)	Date of filing: 17.03.2000

(51)	International Patent Classification (IPC)⁷: A61P 9/10

(86)	International application number:
	PCT/US0007/221

(87)	International publication number:
	WO 0056/403 (28.09.2000 Gazette 2000/39)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

19.03.1999 US 273445

(71)	Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
	Boston, MA 02115 (US)

(72)	Inventors:
	LIAO, James, K. Weston, MA 02193 (US) LAUFS, Ulrich D-50937 Koeln (DE) ENDRES, Matthias D-10437 Berlin (DE) MOSKOWITZ, Michael, A. Belmont, MA 02178 (US)

(74)	Representative: HOFFMANN - EITLE
	Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)

(54)	UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY HMG-CoA REDUCTASE INHIBITORS