(19)

(11)

EP 1 175 405 A1

(12)

(43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00904564.2 (22) Date of filing: 27.01.2000

(51) International Patent Classification (IPC)7: C07D 223/06, C07D 401/02, C07D 403/02, A61K 31/4427, A61K 31/496, A61K 31/55 (86) International application number: PCT/US0001/859 (87) International publication number: WO 0047/563 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.02.1999 US 119374 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: BISACCHI, Gregory, S. Ringoes, NJ 08551 (US) SEILER, Steven, M. Pennington, NJ 08534 (US) LAWRENCE, R., Michael Yardley, PA 19067 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)