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(11)

EP 1 175 414 A1

(12)

(43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 01906972.3 (22) Date of filing: 02.02.2001

(51) International Patent Classification (IPC)7: C07D 305/14, A61K 31/335, C07D 407/12, C07D 409/12 (86) International application number: PCT/US0103/624 (87) International publication number: WO 0157/013 (09.08.2001 Gazette 2001/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.02.2000 US 179684 P 02.02.2000 US 179793 P 02.02.2000 US 179782 P 02.02.2000 US 179669 P 02.02.2000 US 179670 P 02.02.2000 US 179671 P 02.02.2000 US 179674 P 02.02.2000 US 179672 P (71) Applicant: Florida State University Research Foundation, Inc. Tallahassee, FL 32310 (US)

(72) Inventor: Holton, Robert, A.Florida St. Uni. Res.Fou. Inc. Tallahassee, FL 32306-2763 (US) (74) Representative: Maiwald, Walter, Dr. Dipl.-Chem.  Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München 80335 München (DE)