(19)

(11)

EP 1 175 441 A1

(12)

(43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00928612.1 (22) Date of filing: 28.04.2000

(51) International Patent Classification (IPC)7: C07K 14/47 (86) International application number: PCT/US0011/647 (87) International publication number: WO 0066/628 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.05.1999 US 132137 P (71) Applicant: University of Medicine and Dentistry of New Jersey New Brunswick, NJ 08903-2688 (US)	(72) Inventors: GELLER, Herbert, M. Highland Park, NJ 08094 (US) MEINERS, Sally Piscataway, NJ 08854 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)