(19)

(11)

EP 1 175 503 A1

(12)

(43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00920164.1 (22) Date of filing: 06.04.2000

(51) International Patent Classification (IPC)7: C12P 21/06, C12P 21/04, C12N 1/20, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74, C12N 5/00, C12N 5/02, C07K 1/00, C07K 14/00, C07K 17/00, C07H 21/04 (86) International application number: PCT/US0009/068 (87) International publication number: WO 0061/779 (19.10.2000 Gazette 2000/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.04.1999 US 128699 P 20.01.2000 US 177050 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)