(19)

(11)

EP 1 175 507 A2

(12)

(88) Date of publication A3: 16.08.2001 (43) Date of publication: 30.01.2002 Bulletin 2002/05 (21) Application number: 00935822.7 (22) Date of filing: 03.04.2000

(51) International Patent Classification (IPC)7: C12Q 1/04, G01N 33/58 (86) International application number: PCT/US0008/782 (87) International publication number: WO 0063/422 (26.10.2000 Gazette 2000/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.04.1999 US 130009 P (71) Applicant: IIT RESEARCH INSTITUTE Chicago, IL 60616-3799 (US)	(72) Inventors: RAJAN, Krishnaswamy, S. Elmhurst, IL 60126 (US) MAINER, Stephen, S. Crest Hill, IL 60435 (US) (74) Representative: Klusmann, Peter, Dr.  Hoffmann - Eitle Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)