| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GR IE IT LI LU NL PT SE |
|
Designated Extension States: |
|
AL LT LV MK RO SI |
| (30) |
Priority: |
22.07.1997 US 53351 P
23.07.1997 US 53535 P
20.08.1997 GB 9717590
22.08.1997 GB 9717850
|
| (43) |
Date of publication of application: |
|
30.01.2002 Bulletin 2002/05 |
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
98935752.0 / 0998292 |
| (73) |
Proprietor: Merck & Co. Inc. |
|
Rahway
New Jersey 07065-0900 (US) |
|
| (72) |
Inventors: |
|
- Daifotis, Anastasia G.
Rahway, NJ 07065 (US)
- Santora, Arthur C., II
Rahway, NJ 07065 (US)
- Yates, John A.
Rahway, NJ 07065 (US)
|
| (74) |
Representative: Horgan, James Michael Frederic et al |
|
Merck & Co., Inc.
European Patent Department
Merck Sharp & Dohme Limited,
Hertford Road,
Hoddesdon
Hertfordshire, EN11 9BU
Hertfordshire, EN11 9BU (GB) |
| (56) |
References cited: :
EP-A1- 0 274 158
WO-A1-95/08331
|
WO-A1-94/00129
WO-A1-95/28936
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- SINGER F R ET AL: "Bisphosphonates in the treatment of disorders of mineral metabolism."
ADVANCES IN ENDOCRINOLOGY AND METABOLISM, (1995) 6 259-88. REF: 109 JOURNAL CODE:
CB4. ISSN: 1049-6734., XP002092145 United States
- LIBERMAN U A ET AL: "EFFECT OF ORAL ALENDRONATE ON BONE MINERAL DENSITY AND THE INCIDENCE
OF FRACTURES IN POSTMENOPAUSAL OSTEOPOROSIS" THE NEW ENGLAND JOURNAL OF MEDICINE,
vol. 333, no. 22, 30 November 1995 (1995-11-30), pages 1437-1443, XP000579307
- BANKHURST A ET AL: "THREE-YEAR TREATMENT WITH ALENDRONATE PREVENTS FRACTURES IN WOMEN
WITH POSTMENOPAUSAL OSTEOPOROSIS" ARTHRITIS AND RHEUMATISM, vol. 38, no. 9, SUPPL,
1 September 1995 (1995-09-01), page S359 XP000579368
- FILIPPONI P ET AL: "CYCLICAL CLODRONATE IS EFFECTIVE IN PREVENTING POSTMENOPAUSAL
BONE LOSS: A COMPARATIVE STUDY WITH TRANSCUTANEOUS HORMONE REPLACEMENT THERAPY" JOURNAL
OF BONE AND MINERAL RESEARCH, vol. 10, no. 5, May 1995 (1995-05), pages 697-703, XP002042531
- MCCLUNG M R ET AL: "Tiludronate therapy for Paget's disease of bone [published erratum
appears in Bone 1996 Mar;18(3):292]." BONE, (1995 NOV) 17 (5 SUPPL) 493S-496S. JOURNAL
CODE: ASR. ISSN: 8756-3282., XP002092146 United States
- SELTENMEYER, Y. ET AL: "A comparison of the antiresorptive potency of various bisphosphonates
in vivo with their inhibitory effect in vitro on squalene synthase and cellular sterol
synthesis." BONE (NEW YORK), (1997) VOL. 20, NO. 4 SUPPL., PP. 114S. MEETING INFO.:
25TH EUROPEAN SYMPOSIUM ON CALCIFIED TISSUES HARROGATE, ENGLAND, UK APRIL 25-29, 1997
ISSN: 8756-3282., XP002092147
- ADACHI J.D.: "osteoporosis-Its Diagnosis, Management and Treatment with New Oral Bisphophonate
Agent, Etidronate" TODAY'S THERPAEUTIC TRENDS, vol. 14, no. 1, 1996, pages 13-24,
XP002092148
- BELL, NORMAN H. ET AL: "Bisphosphonates in the treatment of osteoporosis" ENDOCRINE
(1997), 6(2), 203-206 CODEN: EOCRE5;ISSN: 1355-008X, XP002092149
- "Update: Bisphosphonates" LUNAR NEWS, vol. April97, 1 April 1997 (1997-04-01),
- "Update: Bisphosphonates" LUNAR NEWS, vol. July96, 1 July 1996 (1996-07-01),
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