<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.1//EN" "ep-patent-document-v1-1.dtd">
<ep-patent-document id="EP00927584B8W1" file="EP00927584W1B8.xml" lang="en" country="EP" doc-number="1176964" kind="B8" correction-code="W1" date-publ="20071010" status="c" dtd-version="ep-patent-document-v1-1">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYAL..............................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 (Ver 1.5  21 Nov 2005) -  2999001/0</B007EP><B078EP><date>20070607</date></B078EP></eptags></B000><B100><B110>1176964</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20071010</date></B140><B150><B151>W1</B151><B153>72</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>00927584.3</B210><B220><date>20000515</date></B220><B240><B241><date>20011119</date></B241><B242><date>20020506</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>9911183</B310><B320><date>19990513</date></B320><B330><ctry>GB</ctry></B330><B310>9911346</B310><B320><date>19990514</date></B320><B330><ctry>GB</ctry></B330><B310>9918534</B310><B320><date>19990805</date></B320><B330><ctry>GB</ctry></B330><B310>9927005</B310><B320><date>19991115</date></B320><B330><ctry>GB</ctry></B330><B310>9927106</B310><B320><date>19991116</date></B320><B330><ctry>GB</ctry></B330><B310>0007637</B310><B320><date>20000329</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20071010</date><bnum>200741</bnum></B405><B430><date>20020206</date><bnum>200206</bnum></B430><B450><date>20060906</date><bnum>200636</bnum></B450><B452EP><date>20051223</date></B452EP><B472><B475><date>20060906</date><ctry>IT</ctry></B475></B472><B480><date>20071010</date><bnum>200741</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  31/495       20060101AFI20051123BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  35/00        20060101ALI20051123BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>VERWENDUNGEN VON ET743 ZUR BEHANDLUNG VON KREBS</B542><B541>en</B541><B542>USES OF ET743 FOR TREATING CANCER</B542><B541>fr</B541><B542>UTILISATION DU COMPOSE ET743 POUR LE TRAITEMENT DU CANCER</B542></B540><B560><B561><text>WO-A-99/51238</text></B561><B561><text>WO-A-99/58125</text></B561><B561><text>US-A- 5 256 663</text></B561><B561><text>US-A- 5 478 932</text></B561><B562><text>IZBICKA: "In vitro antitumor actitivity of the novel marine agent, Ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients " ANNALS OF ONCOLOGY, vol. 9, no. 9, 1998, pages 981-987, XP000900662</text></B562><B562><text> " Ecteinascidin-743 " DRUGS OF THE FUTURE, vol. 22, no. 11, 1997, page 1279 XP002145352</text></B562><B562><text>GIAVAZZI: " Ecteinascidin-743, a New Marine Natural Product with Potent Antitumor Activity " CLINICAL CANCER RESEARCH, vol. 4, no. 8, 1998, pages 1977-1983, XP000930036</text></B562></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>06011784.3</anum><pnum>1702618</pnum></dnum><date>20060607</date></cdoc><cdoc><dnum><anum>06014005.0</anum><pnum>1716853</pnum></dnum><date>20060607</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>CVITKOVIC, Esteban</snm><adr><str>18-20, rue Pasteur</str><city>F-94278 Le Kremlin-Bicêtre</city><ctry>FR</ctry></adr></B721><B721><snm>Demetri, George Daniel,
Dept. of Adult Oncology</snm><adr><str>Dana Faber Cancer Institute,
44 Binney Street</str><city>Boston, MA 02115</city><ctry>US</ctry></adr></B721><B721><snm>GUZMAN, Cecilia,
Pharma Mar, S.A.</snm><adr><str>Calle de la Calera, 3</str><city>Tres Cantos,
E-28760 Madrid</city><ctry>ES</ctry></adr></B721><B721><snm>JIMENO, José,
Pharma Mar, S.A.</snm><adr><str>Calle de la Calera 3</str><city>Tres Cantos,
E-28760 Madrid</city><ctry>ES</ctry></adr></B721><B721><snm>LOPEZ LAZARO, Luis,
Pharma Mar, S.A.</snm><adr><str>Calle de la Calera 3</str><city>Tres Cantos,
E-28760 Madrid</city><ctry>ES</ctry></adr></B721><B721><snm>MISSET, Jean Louis,
Service d'Oncologie</snm><adr><str>Hôspital Paul Brousse,
12-14 Av. Paul V. Couturier</str><city>F-94804 Villejuif Cedex</city><ctry>FR</ctry></adr></B721><B721><snm>TWELVES, C.,
Uni. of Glasgow,
CRC Beatson Lab.</snm><adr><str>Alexander Stone Bld.,
Switchback Road</str><city>Bearsden,
Glasgow G61 1BD</city><ctry>GB</ctry></adr></B721><B721><snm>VON HOFF, Daniel D.,
Arizona Cancer Center</snm><adr><str>College of Medicine,
1515 North Campbell Avenue</str><city>Tuscon, A Z 85724-5024</city><ctry>US</ctry></adr></B721></B720><B730><B731><snm>PHARMA MAR, S.A.</snm><iid>01310671</iid><irf>EPP280673</irf><adr><str>Calle de la Calera 3, 
Poligono Industrial de Tres Cantos</str><city>28760 Tres Cantos,
Madrid</city><ctry>ES</ctry></adr></B731></B730><B740><B741><snm>Ruffles, Graham Keith</snm><sfx>et al</sfx><iid>00043043</iid><adr><str>Marks &amp; Clerk, 
66-68 Hills Road</str><city>Cambridge,
Cambridgeshire CB2 1LA</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>SE</ctry></B840><B844EP><B845EP><ctry>AL</ctry><date>20011116</date></B845EP><B845EP><ctry>LT</ctry><date>20011116</date></B845EP><B845EP><ctry>LV</ctry><date>20011116</date></B845EP><B845EP><ctry>MK</ctry><date>20011116</date></B845EP><B845EP><ctry>RO</ctry><date>20011116</date></B845EP><B845EP><ctry>SI</ctry><date>20011116</date></B845EP></B844EP><B860><B861><dnum><anum>GB2000001857</anum></dnum><date>20000515</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2000069441</pnum></dnum><date>20001123</date><bnum>200047</bnum></B871></B870><B880><date>20020206</date><bnum>200206</bnum></B880></B800></SDOBI>
</ep-patent-document>
