(19)

(11)

EP 1 177 173 A1

(12)

(43) Date of publication: 06.02.2002 Bulletin 2002/06 (21) Application number: 00931910.4 (22) Date of filing: 12.05.2000

(51) International Patent Classification (IPC)7: C07D 211/16, C07C 317/44, C07C 311/21, C07C 311/16, C07D 207/14, C07D 211/46, C07D 211/18, C07D 401/12, C07D 211/54, C07D 295/22, C07D 401/04, C07D 405/12, C07D 409/12, C07D 405/14, C07D 309/12, C07D 401/14, A61K 31/16, A61K 31/445, A61P 19/02 (86) International application number: PCT/US0006/713 (87) International publication number: WO 0069/819 (23.11.2000 Gazette 2000/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.05.1999 US 310813 (71) Applicant: G.D. SEARLE & CO. Chicago, IL 60680-5110 (US)

(72) Inventors: BEDELL, Louis, J. Mt. Prospect, IL 60056 (US) MCDONALD, Joseph, J. Ballwin, MO 63021 (US) BARTA, Thomas, E. Evanston, IL 60202 (US) BECKER, Daniel, P. Glenview, IL 60025 (US) RAO, Shashidhar, N. St. Louis, MO 63141 (US) FRESKOS, John, N. Clayton, MO 63105 (US) MISCHKE, Brent, V. Defiance, MO 63341 (US) GETMAN, Daniel, P. Chesterfield, MO 63017 (US) DECRESCENZO, Gary, A. St. Charles, MO 63304 (US) VILLAMIL, Clara, I. Glenview, IL 60025 (US) (74) Representative: Beil, Hans Christoph, Dr. et al Hansmann & Vogeser, Patent- und Rechtsanwälte, Postfach 80 01 40 65901 Frankfurt 65901 Frankfurt (DE)