(19)

(11)

EP 1 177 215 A1

(12)

(43) Date of publication: 06.02.2002 Bulletin 2002/06 (21) Application number: 00932265.2 (22) Date of filing: 10.05.2000

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 19/00, C12N 15/62 (86) International application number: PCT/US0012/793 (87) International publication number: WO 0068/269 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.05.1999 US 133313 P (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92037 (US)	(72) Inventors: VALE, Wylie, W. La Jolla, CA 92037 (US) NIELSEN, Soren, M. 3400H oeleroed (DK) NIELSEN, Lisa, Z. 3400 Hoeleroed (DK) PERRIN, Marilyn, H. La Jolla, CA 92037 (US) (74) Representative: Fiener, Josef  Maximilianstrasse 57, P.O. Box 12 49 87712 Mindelheim 87712 Mindelheim (DE)