(19)

(11)

EP 1 177 290 A2

(12)

(88) Date of publication A3: 28.06.2001 (43) Date of publication: 06.02.2002 Bulletin 2002/06 (21) Application number: 00928524.8 (22) Date of filing: 28.04.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C12N 5/10, C07K 14/78, A61K 38/39, A61P 3/10, A61P 9/00, A61P 17/02, A61L 29/00, A61L 31/00 (86) International application number: PCT/US0011/459 (87) International publication number: WO 0066/731 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.04.1999 US 131720 P 21.08.1999 US 149738 P 24.09.1999 US 155945 P (71) Applicant: Biostatum, Inc. Durham, NC 27703 (US)	(72) Inventor: BOUTAUD, Ariel,Partners II Building Raleigh, NC 27606 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius Patentanwaltskanzlei Holbeinstrasse 5 81679 München 81679 München (DE)