(19)

(11)

EP 1 178 820 A1

(12)

(43) Date of publication: 13.02.2002 Bulletin 2002/07 (21) Application number: 00928847.3 (22) Date of filing: 04.05.2000

(51) International Patent Classification (IPC)7: A61K 38/51, C12N 9/00, C12N 1/20 (86) International application number: PCT/US0012/250 (87) International publication number: WO 0067/780 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.05.1999 US 132714 P (71) Applicants: SmithKline Beecham Corporation Philadelphia, PA 19103 (US) SmithKline Beecham p.l.c. Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: KONSTANTINIDIS, Alexendros, K. King of Prussia, PA 19406 (US) LONSDALE, John, Timothy Exton, PA 19341 (US) VAN ALLER, Glenn, Scott Reading, PA 19606 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)