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(11)

EP 1 178 851 A1

(12)

(43) Date of publication: 13.02.2002 Bulletin 2002/07 (21) Application number: 00915002.0 (22) Date of filing: 17.03.2000

(51) International Patent Classification (IPC)7: A61L 33/08, A61L 27/34, A61L 31/10 (86) International application number: PCT/US0007/228 (87) International publication number: WO 0056/377 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.03.1999 US 125355 P 29.10.1999 US 430857 (71) Applicant: GENZYME CORPORATION Framingham, MA 01701-9322 (US)	(72) Inventors: WAN, Barbara Evanston, IL 60201 (US) MILLER, Robert, J. Halifax, MA 02338 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing.  Patent- und Rechtsanwälte, Possartstrasse 20 81679 München 81679 München (DE)