(19)

(11)

EP 1 178 971 A1

(12)

(43) Date of publication: 13.02.2002 Bulletin 2002/07 (21) Application number: 00931917.9 (22) Date of filing: 18.05.2000

(51) International Patent Classification (IPC)7: C07D 239/54, C07D 253/06, C07D 417/12, A61K 31/505, A61P 7/02 (86) International application number: PCT/US0008/226 (87) International publication number: WO 0069/833 (23.11.2000 Gazette 2000/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.05.1999 US 134957 P (71) Applicant: Pharmacia Corporation Chicago, IL 60680 (US)	(72) Inventors: SOUTH, Michael, S. St. Louis, MO 63146 (US) JONES, Darin, E. Ballwin, MO 63011 (US) RUEPPEL, Melvin, L. St. Louis, MO 63122 (US) (74) Representative: Albrecht, Thomas, Dr. et al Kraus & Weisert, Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)