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(11)

EP 1 179 002 A1

(12)

(43) Date of publication: 13.02.2002 Bulletin 2002/07 (21) Application number: 00928848.1 (22) Date of filing: 04.05.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C12P 21/06, C12N 1/20, C12N 15/00 (86) International application number: PCT/US0012/251 (87) International publication number: WO 0068/243 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.05.1999 US 133070 P (71) Applicants: SmithKline Beecham Corporation Philadelphia, PA 19103 (US) SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: BROWN, James, R. Berwyn, PA 19312 (US) CHALKER, Alison F. Trappe, PA 19426 (US) KATZ, Lisa, K. Newtown, PA 18940 (US) MAZZULLA, Marie, Jean Collegeville, PA 19426 (US) PAYNE, David, J. Phoenixville, PA 19460 (US) TRAINI, Christopher, M. Media, PA 19063 (US) DU, Wengsheng Mont Clare, PA 19453 (US) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)