(19)
(11) EP 1 179 022 A2

(12)

(88) Date of publication A3:
09.08.2001

(43) Date of publication:
13.02.2002 Bulletin 2002/07

(21) Application number: 00948495.7

(22) Date of filing: 11.05.2000
(51) International Patent Classification (IPC)7C07K 14/81, A61K 38/55, A61P 39/00, C12N 15/63, C12N 5/10
(86) International application number:
PCT/US0012/909
(87) International publication number:
WO 0069/895 (23.11.2000 Gazette 2000/47)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 14.05.1999 US 134216 P

(71) Applicant: Department of the Army
Fort Detrick, MD 21702-5012 (US)

(72) Inventors:
  • GARCIA, Gregory, E.
     (US)
  • GORDON, Richard, K.
    Potomac, MD 20854 (US)
  • MOORAD, Deborah, R.
    Rockville MD 20850-3552 (US)
  • DOCTOR, Bhupendra, P.
    Potomac, MD 20854 (US)

(74) Representative: Sexton, Jane Helen 
J.A. KEMP & CO. 14 South Square Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) BUFORNIN 1 AS A SPECIFIC INHIBITOR AND THERAPEUTIC AGENT FOR BOTULINUM TOXIN B AND TETANUS NEUROTOXINS