(19)
(11) EP 1 179 095 A1

(12)

(43) Date of publication:
13.02.2002 Bulletin 2002/07

(21) Application number: 00937524.7

(22) Date of filing: 04.05.2000
(51) International Patent Classification (IPC)7C12Q 1/68, C12P 19/34
(86) International application number:
PCT/US0012/103
(87) International publication number:
WO 0068/428 (16.11.2000 Gazette 2000/46)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 10.05.1999 US 133391 P

(71) Applicants:
  • SmithKline Beecham Corporation
    Philadelphia, PA 19103 (US)
  • SMITHKLINE BEECHAM PLC
    Brentford, Middlesex TW8 9BD (GB)

(72) Inventors:
  • CHALKER, Alison, F.
    Trappe, PA 19426 (US)
  • GE, James, Yigong
    Royersford, PA 19468 (US)
  • HOLMES, David, J.
    West Chester, PA 19380 (US)
  • LUNSFORD, Robert, D.
    Pottstown, PA 19380 (US)

(74) Representative: Mallalieu, Catherine Louise et al
D. Young & Co., 21 New Fetter Lane
London EC4A 1DA
London EC4A 1DA (GB)

   


(54) METHODS FOR PRODUCING MODIFIED NUCLEIC ACID MOLECULES