(19)
(11) EP 1 180 140 A1

(12)

(43) Date of publication:
20.02.2002 Bulletin 2002/08

(21) Application number: 00920190.6

(22) Date of filing: 06.04.2000
(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/63, C12N 15/64, C07K 14/435, A61K 38/16, A61K 38/17, A61K 48/00
(86) International application number:
PCT/US0009/178
(87) International publication number:
WO 0066/737 (09.11.2000 Gazette 2000/45)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 30.04.1999 US 131940 P

(71) Applicant: Aventis Pharmaceuticals Products Inc.
Bridgewater, NJ 08807-0800 (US)

(72) Inventors:
  • SEARFOSS, George, H., III
    Birdsboro, PA 19508 (US)
  • PAGNONI, Marco, F.
    Norristown, PA 19403 (US)
  • IVASHCHENKO, Yuri, D.
    Norristown, PA 19525 (US)
  • GUO, Kun
    Eagleville, PA 19403 (US)
  • CLARK, Kenneth, L.
    Hertfordshire SG1 4AS (GB)

(74) Representative: Jones, Stephen Anthony 
AdamsonJones Broadway Business Centre 32a Stoney Street
Nottingham NG1 1LL
Nottingham NG1 1LL (GB)

   


(54) VARIANTS OF TRAF2 WHICH ACT AS AN INHIBITOR OF TNF-ALPHA SIGNALING PATHWAY