(19)

(11)

EP 1 180 150 A2

(12)

(88) Date of publication A3: 22.02.2001 (43) Date of publication: 20.02.2002 Bulletin 2002/08 (21) Application number: 00926234.6 (22) Date of filing: 21.04.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/85, C12N 15/88, A61K 39/02, A61K 39/09, A61K 39/095, A61K 39/102 (86) International application number: PCT/US0010/766 (87) International publication number: WO 0063/385 (26.10.2000 Gazette 2000/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.04.1999 US 130249 P (71) Applicant: Powderject Vaccines, Inc. Madison, Wisconsin 53711 (US)	(72) Inventors: CHEN, Dexiang Madison, WI 53719 (US) FULLER, James, T. Oregon, WI 53575 (US) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO., Gray's Inn, 14 South Square London WC1R 5JJ London WC1R 5JJ (GB)