(19)

(11)

EP 1 180 165 A2

(12)

(88) Date of publication A3: 31.05.2001 (43) Date of publication: 20.02.2002 Bulletin 2002/08 (21) Application number: 00937874.6 (22) Date of filing: 26.05.2000

(51) International Patent Classification (IPC)7: C12Q 1/37, C12Q 1/02 (86) International application number: PCT/US0014/678 (87) International publication number: WO 0073/493 (07.12.2000 Gazette 2000/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.05.1999 US 136173 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: GURNEY, Mark, E. Grand Rapids, MI 49506 (US) GEARY, Timothy, G. Kalamazoo, MI 49004 (US) ELLERBROCK, Brenda, R. Augusta, MI 49012 (US) THOMAS, Eileen, M. Kalamazoo, MI 49001 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)