(19)

(11)

EP 1 181 050 A1

(12)

(43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 00928658.4 (22) Date of filing: 28.04.2000

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/395, A61K 38/00, C07K 5/00, C07K 5/08 (86) International application number: PCT/US0011/734 (87) International publication number: WO 0066/155 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.04.1999 US 131730 P (71) Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY San Diego, CA 92121 (US)	(72) Inventors: SARAWAR, Sally, R. San Diego, CA 92121 (US) SCHOENBERGER, Stephen, Philip Encinitas, CA 92024 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)