(19)

(11)

EP 1 181 053 A2

(12)

(88) Date of publication A3: 05.04.2001 (43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 00930437.9 (22) Date of filing: 05.05.2000

(51) International Patent Classification (IPC)7: A61K 39/39, A61K 39/395, A61P 35/00 (86) International application number: PCT/US0012/435 (87) International publication number: WO 0067/788 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.05.1999 US 132944 P (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US)	(72) Inventors: STURMHOEFEL, Knut Andover, MA 01810 (US) WOLF, Stanley, F. Arlington, MA 02474 (US) O'TOOLE, Margot Newton, MA 02460 (US) (74) Representative: Dörries, Hans Ulrich, Dr.  Dörries, Frank-Molnia & Pohlman, Triftstrasse 13 80538 München 80538 München (DE)