(19)

(11)

EP 1 181 055 A2

(12)

(88) Date of publication A3: 31.05.2001 (43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 00923446.9 (22) Date of filing: 17.04.2000

(51) International Patent Classification (IPC)7: A61K 47/48 (86) International application number: PCT/US0010/327 (87) International publication number: WO 0069/472 (23.11.2000 Gazette 2000/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.05.1999 US 134135 P (71) Applicant: BOEHRINGER INGELHEIM PHARMACEUTICALS INC. Ridgefield, Connecticut 06877-0368 (US)	(72) Inventors: FIRESTONE, Raymond, A. Stamford, CT 06902 (US) TELAN, Leila, A. Somerville, MA 02143 (US) (74) Representative: Laudien, Dieter, Dr.  Boehringer Ingelheim GmbH Abteilung Patente 55216 Ingelheim 55216 Ingelheim (DE)