(19)

(11)

EP 1 181 311 A1

(12)

(43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 00939704.3 (22) Date of filing: 09.06.2000

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 16/00, C12P 7/00, C12P 29/00, G01N 33/537, G01N 33/574, G01N 33/577 (86) International application number: PCT/US0015/820 (87) International publication number: WO 0075/179 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.06.1999 US 151402 P (71) Applicant: Georgetown University Washington, DC 20007 (US)	(72) Inventors: WAINER, Irving Washington, DC 20008 (US) ZHANG, Yanxiao Washington, DC 20016 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)