(19)

(11)

EP 1 181 352 A1

(12)

(43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 99945293.1 (22) Date of filing: 27.08.1999

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 5/02, A61K 49/00 (86) International application number: PCT/US9919/778 (87) International publication number: WO 0068/361 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.05.1999 US 132828 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US)	(72) Inventors: BURGESON, Robert Marblehead, MA 01945 (US) KISHIMOTO, Jiro Wellesley, MA 02181 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)