(19)

(11)

EP 1 181 391 A2

(12)

(88) Date of publication A3: 11.10.2001 (43) Date of publication: 27.02.2002 Bulletin 2002/09 (21) Application number: 00925493.9 (22) Date of filing: 26.04.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 14/37, C12N 15/53, G06F 19/00, G06F 17/30 (86) International application number: PCT/GB0001/620 (87) International publication number: WO 0066/773 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.04.1999 GB 9910100 13.03.2000 GB 0006004 31.03.2000 GB 0007901 (71) Applicant: Syngenta Limited Haslemere, Surrey GU27 3JE (GB)

(72) Inventors: WINDASS, John, David Bracknell,Berkshire RG42 6YA (GB) HEANEY, Stephen, Paul Bracknell,Berkshire RG42 6YA (GB) RENWICK, Annabel F-92160 Antony (FR) WHITCOMBE, David, Mark Northwich,Cheshire CW9 7RA (GB) LITTLE, Stephen Northwich,Cheshire CW9 7RA (GB) GIBSON, Neil, James Northwich,Cheshire CW9 7RA (GB) THEAKER, Jane Northwich,Cheshire CW9 7RA (GB) STANGER, Carole, Patricia Bracknell, Berkshire RG42 6YA (GB) (74) Representative: Gaal, Jozsef Christopher et al Syngenta Limited Intellectual Property Department Jealott's Hill International Research Centre PO Box No. 3538 Bracknell, Berkshire RG42 6YA Bracknell, Berkshire RG42 6YA (GB)