(19)

(11)

EP 1 183 074 A1

(12)

(43) Date of publication: 06.03.2002 Bulletin 2002/10 (21) Application number: 00913676.3 (22) Date of filing: 01.03.2000

(51) International Patent Classification (IPC)7: A61P 17/14, C07C 233/25, C07C 233/29, C07D 295/08, A61K 31/165, A61K 31/535, A61K 31/40 (86) International application number: PCT/US0005/251 (87) International publication number: WO 0072/920 (07.12.2000 Gazette 2000/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.06.1999 US 136958 P (71) Applicant: UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER Dallas, TX 75235-9094 (US)	(72) Inventors: YOUNGQUIST, Robert, Scott Mason, OH 45040 (US) MCIVER, John, McMillan Cincinnati, OH 45241 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)