(19)

(11)

EP 1 183 364 A1

(12)

(43) Date of publication: 06.03.2002 Bulletin 2002/10 (21) Application number: 00931425.3 (22) Date of filing: 26.05.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/245, C12N 15/62, A61K 38/16, C07K 16/12 (86) International application number: PCT/GB0002/019 (87) International publication number: WO 0073/463 (07.12.2000 Gazette 2000/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.05.1999 GB 9912445 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: BUCKLE, Ashley Maurice Cambridge CB2 5NX (GB) FERSHT, Alan,MRC Unit - Protein Function & Design Cambridge CB2 1EW (GB) (74) Representative: Maschio, Antonio  D Young & Co, 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)