| (84) |
Designated Contracting States: |
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AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
| (30) |
Priority: |
13.05.1999 US 311428
|
| (43) |
Date of publication of application: |
|
06.03.2002 Bulletin 2002/10 |
| (73) |
Proprietor: The Trustees of Columbia University in the City of
New York |
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New York, NY 10027-6699 (US) |
|
| (72) |
Inventors: |
|
- O'CONNOR, John
New Rochelle, NY 10850 (US)
- BIRKEN, Steven
Dumont, NJ 07628 (US)
- KOVALEVSKAYA, Galina
New York, NY 10463 (US)
|
| (74) |
Representative: Lawrence, John |
|
Barker Brettell,
138 Hagley Road,
Edgbaston
Birmingham B16 9PW
Birmingham B16 9PW (GB) |
| (56) |
References cited: :
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- KOVALEVSKAYA G ET AL: "EARLY PREGNANCY HUMAN CHORIONIC GONADOTROPIN (HCG) ISOFORMS
MEASURED BY AN IMMUNOMETRIC ASSAY FOR CHORIOCARCINOMA-LIKE HCG" JOURNAL OF ENDOCRINOLOGY,
BRISTOL, GB, vol. 161, 1999, pages 99-106, XP000939395 ISSN: 0022-0795
- O'CONNOR J F ET AL: "DIFFERENTIAL URINARY GONADOTROPHIN PROFILES IN EARLY PREGNANCY
AND EARLY PREGNANCY LOSS" PRENATAL DIAGNOSIS, CHICHESTER, SUSSEX, GB, vol. 18, no.
12, December 1998 (1998-12), pages 1232-1240, XP001098498 ISSN: 0197-3851
- COLE LAURENCE A: "hCG, its free subunits and its metabolites. Roles in pregnancy and
trophoblastic disease." JOURNAL OF REPRODUCTIVE MEDICINE, vol. 43, no. 1, January
1998 (1998-01), pages 3-10, XP008014363 ISSN: 0024-7758
- BIRKEN S. ET AL.: 'Development and characterization of antibodies to a nicked and
hyperglycosylated form of hCG from a choriocarcinoma patient' ENDOCRINE, vol. 10,
no. 2, April 1999, pages 137 - 144, XP002930368
- KOVALEVSKAYA G. ET AAL.: 'Evaluation of nicked human chorionic gonadotropin content
in clinical specimens by a specific immunometric assay' CLINICAL CHEMISTRY, vol. 45,
no. 1, January 1999, pages 68 - 77, XP002930369
- COLE L.A. ET AL.: 'The heterogeneity of human chorionic gonadotropin (hCG). III. The
occurrence and biological and immunological activities of nicked hCG' ENDOCRINOLOGY,
vol. 129, no. 3, 1991, pages 1559 - 1567, XP002930370
- BERGER P. ET AL.: 'Variants of human chorionic gonadotropin from pregnant women and
tumor patients recognized by monoclonal antibodies' JOURNAL OF CLINICAL ENDOCRINOLOGY
AND METABOLISM, vol. 77, no. 2, 1993, pages 347 - 351, XP002930371
- ACEVEDO H.F. ET AL.: 'Expression of membrane-associated human chorionic gonadotropin,
Its subunits and fragments by cultured human cancer cells' CANCER, vol. 69, no. 7,
01 April 1992, pages 1829 - 1842, XP002930372
- HOERMANN R. ET AL.: 'Molecular heterogeneity of human chorionic gonadotropin in serum
and urine from patients with trophoblastic tumors' CLINICAL INVESTIGATION, vol. 71,
1993, pages 953 - 960, XP002930373
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