(19)

(11)

EP 1 183 391 A2

(12)

(88) Date of publication A3: 15.03.2001 (43) Date of publication: 06.03.2002 Bulletin 2002/10 (21) Application number: 00937642.7 (22) Date of filing: 20.05.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, G01N 33/53, C07K 1/00, A61K 38/00 (86) International application number: PCT/US0013/961 (87) International publication number: WO 0071/080 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.05.1999 US 135035 P (71) Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION Salt Lake City, Utah 84112 (US)	(72) Inventors: Bolger, Graeme B. Salt Lake City, UT 84103 (US) Houslay, Miles D.,Pharm. Group, Dvn. of Bioch. Glasgow G12 8QQ (GB) Steele, Michael R. Salt Lake City, UT 84105 (US) Yarwood, Stephen J.,Ontario Canc. Inst. Res. Dep Toronto,Ontario (CA) (74) Representative: Wakerley, Helen Rachael et al Reddie & Grose, 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)