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(11)

EP 1 185 258 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00937605.4 (22) Date of filing: 18.05.2000

(51) International Patent Classification (IPC)7: A61K 31/131, A61K 31/155, A61K 31/198, A61K 31/223, A61P 7/00 (86) International application number: PCT/US0013/685 (87) International publication number: WO 0071/112 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.05.1999 US 315929 (71) Applicant: Cold Spring Harbor Laboratory Cold Spring Harbor, NY 11724 (US)	(72) Inventors: ENIKOLOPOV, Grigori Cold Spring Harbor, NY 11724 (US) PEUNOVA, Natalia, I. Cold Spring Harbor, NY 11724 (US) KUZIN, Boris, A. Moscow 117607 (RU) CLINE, Hollis Cold Spring Harbor, NY 11724 (US) MICHURINA, Tatyana Moscow 117808 (RU) (74) Representative: Lock, Graham James et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)