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(11)

EP 1 185 286 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00939692.0 (22) Date of filing: 09.06.2000

(51) International Patent Classification (IPC)7: A61K 38/00, C07K 14/435, C07K 14/00, C12N 15/12 (86) International application number: PCT/US0015/779 (87) International publication number: WO 0076/532 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.06.1999 US 138507 P (71) Applicants: The University of Utah Research Foundation Salt Lake City, UT 84108 (US) Cognetix, Inc. Salt Lake City, UT 84108 (US)

(72) Inventors: OLIVERA, Baldomero, M. Salt Lake City, UT 84108 (US) MCINTOSH, J., Michael Salt Lake City, UT 84108 (US) MCCABE, R., Tyler Salt Lake City, UT 84108 (US) GARRETT, James, E. Salt Lake City, UT 84106 (US) LAYER, Richard, T. Sandy, UT 84093 (US) WAGSTAFF, John, D. Salt Lake City, UT 84101 (US) JONES, Robert, M. Salt Lake City, UT 84101 (US) (74) Representative: Rambelli, Paolo (IT) et al Jacobacci & Partners S.p.A.Corso Regio Parco 27 I-10152 Torino I-10152 Torino (IT)