(19)

(11)

EP 1 185 304 A2

(12)

(88) Date of publication A3: 12.07.2001 (43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00935338.4 (22) Date of filing: 05.06.2000

(51) International Patent Classification (IPC)7: A61K 48/00 (86) International application number: PCT/GB0002/014 (87) International publication number: WO 0074/724 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.06.1999 GB 9912807 03.06.1999 US 137592 P (71) Applicant: Bioinnovation Limited London W1R 9AJ (GB)	(72) Inventors: Franks, Christopher Ralph EddingtonHungerford RG17 2HP (GB) Della Bitta Ruggero I-20122 Milan (IT) Maitland, Norman JamesCancer Research Unit York YO1 5YW (GB) Knight, David JonathanCancer Research Unit York YO1 5YW (GB) (74) Representative: Couchman, Jonathan Hugh  Harrison Goddard Foote,Belgrave HallBelgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)