(19)

(11)

EP 1 185 513 A2

(12)

(88) Date of publication A3: 23.08.2001 (43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00928437.3 (22) Date of filing: 27.04.2000

(51) International Patent Classification (IPC)7: C07D 213/65, C07D 213/70, C07C 205/06, C07C 211/46, C07C 211/48, C07D 317/64, A61P 25/00, A61K 31/44 (86) International application number: PCT/US0011/256 (87) International publication number: WO 0071/520 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.05.1999 US 317327 07.06.1999 US 327149 (71) Applicant: Targacept, Inc. Winston-Salem, NC 27102-1487 (US)	(72) Inventors: DULL, Gary, Maurice Lewisville, NC 27023 (US) REICH, Erin, E. Nashville, TN 37215 (US) WAGNER, Jared, Miller Stillwater, OK 74074 (US) BHATTI, Balwinder, Singh Winston-Salem, NC 27106 (US) CONSILVIO, Michael, B. Potomac, MD 20854 (US) (74) Representative: Chapman, Paul Gilmour et al Cruikshank & Fairweather,19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)