(19)

(11)

EP 1 185 514 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00938183.1 (22) Date of filing: 06.06.2000

(51) International Patent Classification (IPC)7: C07D 213/74, C07D 213/82, C07D 213/65, C07D 213/70, C07D 213/26, C07D 213/89, A61K 31/44, A61K 31/505 (86) International application number: PCT/US0015/560 (87) International publication number: WO 0075/110 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.06.1999 US 327141 07.06.1999 US 327774 (71) Applicant: Targacept, Inc. Winston-Salem, NC 27102-1487 (US)

(72) Inventors: DULL, Gary, Maurice Lewisville, NC 27023 (US) MILLER, Craig, Harrison Winston-Salem, NC 27103 (US) CALDWELL, William, Scott Winston-Salem, NC 27106 (US) LYNM, Dwo Winston-Salem, NC 27103 (US) BHATTI, Balwinder, Singh Winston-Salem, NC 27106 (US) SCHMITT, Jeffrey, Daniel Winston-Salem, NC 27101 (US) BYRD, Gary, Dwight Winston-Salem, NC 27127 (US) HADIMANI, Srishailkumar, Basawannappa Winston-Salem, NC 27105 (US) (74) Representative: Horner, Martin Grenville et al Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)