(19)

(11)

EP 1 185 543 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00936455.5 (22) Date of filing: 01.06.2000

(51) International Patent Classification (IPC)7: C07H 21/00, C07K 2/00, C12P 19/34, C12N 15/12 (86) International application number: PCT/US0015/136 (87) International publication number: WO 0077/022 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.06.1999 US 138629 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Olney, MD 20832 (US) KOMATSOULIS, George, A. Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)