(19)

(11)

EP 1 185 547 A2

(12)

(88) Date of publication A3: 17.05.2001 (43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00942732.9 (22) Date of filing: 09.06.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 5/00, C07K 14/00, C07K 16/00, C12Q 1/68 (86) International application number: PCT/US0015/973 (87) International publication number: WO 0077/166 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.06.1999 US 138487 P (71) Applicant: Digital Gene Technologies Inc. La Jolla, CA 92037 (US)

(72) Inventors: VINEY, Joanne Seattle, WA 98116 (US) SIMS, John, E. Seattle, WA 98116 (US) DUBOSE, Robert, F. Bellevue, WA 98006 (US) HILBUSH, Brian, S. San Diego, CA 92130 (US) HASEL, Karl, W. Solana Beach, CA 92075 (US) BUCHNER, Robert, R. San Diego, CA 92129 (US) (74) Representative: Kaiser, Jürgen, Dr.rer.nat.Dipl.-Chem.  Winter, Brandl, Fürniss, Hübner,Röss, Kaiser, PoltePartnerschaftPatent- und RechtsanwaltskanzleiAlois-Steinecker-Strasse 22 85354 Freising 85354 Freising (DE)