(19)

(11)

EP 1 185 647 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00940542.4 (22) Date of filing: 14.06.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12Q 1/68, G01N 33/50 (86) International application number: PCT/GB0002/317 (87) International publication number: WO 0077/202 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.06.1999 GB 9913863 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)

(72) Inventors: KREMER, AndreasSmithKline Beecham Pharmaceuticals Harlow,Essex CM19 5AW (GB) JACKSON, AngelaSmithKline Beecham Pharmaceuticals Harlow,Essex CM19 5AW (GB) CAIRNS, WilliamSmithKline Beecham Pharmaceuticals Harlow,Essex CM19 5AW (GB) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)