(19)

(11)

EP 1 185 659 A2

(12)

(88) Date of publication A3: 31.05.2001 (43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00935220.4 (22) Date of filing: 08.06.2000

(51) International Patent Classification (IPC)7: C12N 15/34, A61K 39/12 (86) International application number: PCT/EP0005/611 (87) International publication number: WO 0077/188 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.06.1999 US 138352 P (71) Applicant: MERIAL 69002 Lyon (FR)	(72) Inventors: AUDONNET, Jean-Christophe, Francis F-69006 Lyon (FR) BUBLOT, Michel Delmar, NY 12054 (US) PEREZ, Jennifer, Maria East Nassau, NY 12062 (US) CHARREYRE, Catherine, Elisabeth F-69720 Saint-Laurent de Mure (FR) (74) Representative: Jacobson, Claude et al Cabinet Lavoix2, Place d'Estienne d'Orves 75441 Paris Cedex 09 75441 Paris Cedex 09 (FR)