(19)

(11)

EP 1 185 668 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00938825.7 (22) Date of filing: 14.06.2000

(51) International Patent Classification (IPC)7: C12N 15/53, C12N 15/52, C12N 9/02, C12N 9/04, C12P 19/62 (86) International application number: PCT/EP0006/227 (87) International publication number: WO 0077/222 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.06.1999 EP 99201893 (71) Applicant: DSM N.V. 6411 TE Heerlen (NL)	(72) Inventors: MARTIN, Juan Fransisco E-24004 Léon (ES) APARICIO, Jesus F E-33013 Oviedo (ES) COLINA, Angel Jose E-24009 Léon (ES) LUITEN, Rudolf, Gijsbertus, Marie NL-2317 KR Leiden (NL) (74) Representative: Matulewicz, Emil Rudolf Antonius, Dr. et al DSM N.V.Patents & Trademarks DepartmentOffice Delft 600-0240P.O. Box 1 2600 MA Delft 2600 MA Delft (NL)