(19)

(11)

EP 1 185 681 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00937684.9 (22) Date of filing: 23.05.2000

(51) International Patent Classification (IPC)7: C12P 19/34, C07H 21/04, A01N 43/04, A61K 31/70 (86) International application number: PCT/US0014/133 (87) International publication number: WO 0071/740 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.05.1999 US 135560 P (71) Applicant: THE PUBLIC HEALTH RESEARCH INSTITUTEOF THE CITY OF NEW YORK, INC. New York NY 10016 (US)	(72) Inventors: TYAGI, Sanjay New York, NY 10010 (US) KRAMER, Fred, R. Riverdale, NY 10463 (US) (74) Representative: Bizley, Richard Edward et al Hepworth, Lawrence, Bryer & BizleyMerlin HouseFalconry CourtBaker's Lane EppingEssex CM16 5DQ EppingEssex CM16 5DQ (GB)