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(11)

EP 1 185 700 A1

(12)

(43) Date of publication: 13.03.2002 Bulletin 2002/11 (21) Application number: 00936426.6 (22) Date of filing: 01.06.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, C12N 15/09, C12N 7/00, C12N 5/00, C07H 21/04, C07K 17/00, C07K 1/00, C07K 14/00, C07K 16/00, A61K 39/29 (86) International application number: PCT/US0014/926 (87) International publication number: WO 0077/255 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.06.1999 US 138628 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George, A. Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)