(19)

(11)

EP 1 187 609 A1

(12)

(43) Date of publication: 20.03.2002 Bulletin 2002/12 (21) Application number: 00942673.5 (22) Date of filing: 02.06.2000

(51) International Patent Classification (IPC)7: A61K 31/40 (86) International application number: PCT/US0015/372 (87) International publication number: WO 0074/673 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.06.1999 US 137365 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)	(72) Inventors: HASAN, Tayyaba Arlington, MA 02476 (US) ORTEL, Bernhard Boston, MA 02114 (US) MAYTIN, Edward Newton, MA 02465 (US) (74) Representative: Alcock, David et al D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)