(19)

(11)

EP 1 187 615 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 20.03.2002 Bulletin 2002/12 (21) Application number: 00902660.0 (22) Date of filing: 02.02.2000

(51) International Patent Classification (IPC)7: A61K 31/505, A61K 38/13, A61K 31/52, A61K 31/535 (86) International application number: PCT/EP0000/938 (87) International publication number: WO 0045/800 (10.08.2000 Gazette 2000/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.02.1999 US 118295 P 02.02.1999 US 118235 P 02.02.1999 US 118282 P (71) Applicant: K.U. Leuven Research & Development 3000 Leuven (BE)	(72) Inventors: WAER, Mark, Jozef, Albert B-3001 Heverlee (BE) HERDEWIJN, Piet, André, Maurits, Maria B-3111 Rotselaar/Wezemaal (BE) PFLEIDERER, Wolfgang, Eugen D-78464 Konstanz (DE) (74) Representative: Prins, Hendrik Willem et al Arnold & Siedsma,Advocaten en Octrooigemachtigden,Sweelinckplein 1 2517 GK Den Haag 2517 GK Den Haag (NL)