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(11)

EP 1 187 810 A2

(12)

(88) Date of publication A3: 18.10.2001 (43) Date of publication: 20.03.2002 Bulletin 2002/12 (21) Application number: 00937830.8 (22) Date of filing: 25.05.2000

(51) International Patent Classification (IPC)7: C07D 211/26, C07D 211/60, C07D 211/56, C07D 241/04, C07D 265/30, C07D 267/10, C07D 223/04, C07D 223/12, C07D 243/06, C07D 205/04, C07D 207/09, C07D 207/16, C07D 491/10, A61K 31/445, A61K 31/397, A61K 31/40, A61K 31/535, A61K 31/55, A61K 31/551, A61K 31/553, A61P 25/04 (86) International application number: PCT/US0014/579 (87) International publication number: WO 0071/518 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.05.1999 US 135721 P 03.12.1999 US 168979 P 11.04.2000 US 195809 P (71) Applicant: SEPRACOR, INC. Marlborough, MA 01752 (US)

(72) Inventors: CUNY, Gregory, D. Hudson, MA 01749 (US) SHAO, Liming Lincoln, MA 01773 (US) HAUSKE, James, R. Concord, MA 01742 (US) HEFFERNAN, Michele, L., R. Framingham, MA 01702 (US) AQUILA, Brian, M. Marlborough, MA 01752 (US) WU, Xinhe Marlborough, MA 01752 (US) WANG, Fengjian Northborough, MA 01532 (US) BANNISTER, Thomas, D. Northborough, MA 01532 (US) (74) Representative: Horner, Martin Grenville et al Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)